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Best online pharmacy accutane, the only medication available in United States on the market that can prevent growth of the melanoma tumor. A review published Friday found that accutane, a drug used to block the growth of cancerous cells in cancer patients, was found to cause more than double the cancer deaths in two studies, and may have even increased the risk of death in two other studies. While the studies reviewed are small, authors say more research is needed to confirm or refute the findings. "This report underscores the need for further study of the impact that long-term use of this medication may have on patients' health and overall well-being," says Dr. John J. Bose, the co-director of cancer prevention at the Fred Hutchinson Cancer Research Center in Seattle. Accutane is available in Australia, Canada, New Zealand, France and Spain. Accutane is made up of two drugs: meglumine, an analog of vitamin-C, and dutasteride. Meglumine blocks the formation of vitamin-C, while dutasteride blocks a key enzyme involved in the production of vitamin-C. Meglumine is used to treat a form of male breast cancer. Dutasteride also works by blocking this enzyme. Because vitamin-C-rich foods are not available in the United States, most people who take accutane are online accutane pharmacy exposed to this vitamin orally -- either as a pill or paste. The Food and Drug Administration requires that a label say drug is vitamin-C-containing, but doctors can ignore this information if they want. "The FDA should take action to address the discrepancy between statements company makes on their medication labels, and the content of data about its effects in clinical trials and postmarketing reports, provide a more accurate explanation about where in the medical literature these data were gathered and what they mean in the drug's overall effect on human health," the researchers wrote. The review, published online in Journal of the National Cancer Institute, was conducted by researchers at three cancer centers in the United States and Denmark. They reviewed data collected by the company from 2000 to 2002 and 2001 2003 on 2,300 patients who were treated with the drug and who underwent a skin biopsy. They found an increased risk of cancer deaths from 3.5 to 18.1 per 10,000 patients who were taking accutane and followed for an average of 11 years. "We think the data that we are evaluating here provide some evidence that accutane might have an effect on the risk of cancer mortality, but there is a lot of variability in that effect," Bose says. The researchers did not look at all patients who took the medication, but only at those who died -- patients were the most likely to be exposed vitamin-C-rich foods because they were taking the drug as a pill. The risk of cancer death was much higher in men who had a higher exposure to vitamin-C-rich foods, including bread, milk and cheese. Cancer deaths also increased among those who had taken the drug earlier in life. The researchers also looked at cancer deaths in women who were not taking the medication, and found increased risk was not as large. The studies were conducted mainly in Europe, but the researchers did find an association between vitamin-C-rich foods and cancer deaths in some countries such as Italy, Spain and Sweden. The risk of cancer death was higher in patients who had a higher use of hormone replacement therapy, which is used to treat high blood pressure. In the studies reviewed, all deaths involving the drug occurred in men. While more research is needed, Bose says he does not believe there is a need to stop using vitamin-C-rich foods. "I can't imagine any reason to reduce exposure vitamin-C-rich foods because there is such variation between studies, which is a big factor generic accutane online pharmacy in interpreting this," he says. "So far, all that is known about this medication what it Doxylamine succinate over the counter australia does to people on it, and that it may do some things, while doing nothing or something different in some people." Copyright 2005 HealthDay. All rights reserved.

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